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Mechanism drug examples efficient repair to damaged dna alkylating agents decreased uptake by cell methotrexate, doxorubicin increased drug efflux p-glycoprotein epipodophyllotoxin, vinca alkaloids, anthracyclines decreased intracellular activation 6-mercaptopurine, 5-fluorouracil increased intracellular breakdown cytosine arabinoside bypass biochemical pathways methotrexate, 6-mercaptopurine, asparaginase gene amplification or over- production of blocked enzyme methotrexate, nitrosoureas resistance to cytotoxic agents.

Information about Methotrexate.

If you are using the liquid form of this medicationcarefully measure the dose using a special measuring device/spoonDo not use a household spoon because you may not get the correct dose.

Methotrexate is usually not taken every dayYou must use the correct dose for your conditionSome people have died after taking methotrexate every day by accident.

Methotrexate use has rarely caused serioussometimes fatalside effectssuch as lung problemslung infectionsPneumocystis jiroveci pneumoniaskin reactionsdiarrheaand mouth soresulcerative stomatitisSee also Side Effects section

Nausea or vomiting stomach pain or upset diarrhea hair loss tiredness dizziness chills headache sores in your lungs mouth sores painful skin sores bronchitis fever bruising more easily increased risk of infection sun sensitivity rash stuffy or runny nose and sore throat abnormal results on liver function testsmay indicate liver damagelow blood cell levels.

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5 to 15 mg of methotrexate given weekly , administration of seven days of naproxen 500 mg twice daily and prevacid 30 mg daily had no effect on the pharmacokinetics of methotrexate and 7-hydroxymethotrexate.