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The highest risk is with oral chloramphenicol 7 affecting 1 in 24,000 40,000 8 and the lowest risk occurs with eye drops affecting less than 1 in 224,716 prescriptions .

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Tell your doctor and pharmacist if you are allergic to chloramphenicol injection or any other medicationstell your doctor and pharmacist what other prescription and nonprescription medicationsvitaminsnutritional supplementsand herbal products you are taking or plan to takeBe sure to mention any of the followinganticoagulantsblood thinnerssuch as warfarinCoumadinaztreonamAzactamcephalosporin antibiotics such as cefoperazoneCefobidcefotaximeClaforanceftazidimeFortazTazicefand ceftriaxoneRocephincyanocobalaminvitamin B 12folic acidiron supplementscertain oral medications for diabetes such as chlorpropamideDiabineseand tolbutamidephenobarbitalphenytoinDilantinPhenytekrifampinRimactaneRifadinand medications that may cause a decrease in the number of blood cells in the bodyAsk your doctor or pharmacist if any of the medications that you are taking may cause a decrease in the number of blood cellsYour doctor may need to change the doses of your medications or monitor you carefully for side effectsOther medications may also interact with chloramphenicol injectionso be sure to tell your doctor about all the medications you are takingeven those that do not appear on this listtell your doctor if you have ever been treated with chloramphenicol injection beforeespecially if you experienced severe side effectsYour doctor may tell you not to use chloramphenicol injectiontell your doctor if you have or have ever had kidney or liver diseasetell your doctor if you are pregnantplan to become pregnantor are breast-feedingIf you become pregnant while receiving chloramphenicol injectioncall your doctorif you are having surgeryincluding dental surgerytell the doctor or dentist that you are receiving chloramphenicol injection.

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If a concomitant topical treatment to the eye is requiredthe administration of the different products should be separated by an adequate period of time.

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here, we provide mechanistic insights into high-level resistance to chloramphenicol in c.