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Information about Toprol.

The precise mechanism for the beneficial effects of beta-blockers in heart failure has not been elucidated.

Other medications can affect the removal of metoprolol from your bodywhich may affect how metoprolol worksExamples include lumefantrinepropafenonequinidineSSRI antidepressantssuch as fluoxetineparoxetineStJohn’s wortamong others.

Safety and effectiveness of TOPROL-XL have not been established in patients.

If clonidine and a beta blockersuch as metoprolol are coadministeredwithdraw the beta-blocker several days before the gradual withdrawal of clonidine because beta-blockers may exacerbate the rebound hypertension that can follow the withdrawal of clonidineIf replacing clonidine by betablocker therapydelay the introduction of beta-blockers for several days after clonidine administration has stoppedsee WARNINGS AND PRECAUTIONS

A very serious allergic reaction to this drug is rareHoweverget medical help right away if you notice any symptoms of a serious allergic reactionincludingrashitching/swellingespecially of the face/tongue/throatsevere dizzinesstrouble breathing.

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double the dose every two weeks to the highest dosage level tolerated by the patient or up to 200 mg of toprol-xl.