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Such behavior was a potential concern, because doing so would put a patient at risk for overdose when naltrexone vacated the receptors at the ends of the dosing periods.

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Nose bleedsphlebitisedemaincreased blood pressurenon-specific ECG changespalpitationstachycardia.

If a more rapid transition from agonist to antagonist therapy is deemed necessary and appropriate by the healthcare providermonitor the patient closely in an appropriate medical setting where precipitated withdrawal can be managed.

In an emergency situation in patients receiving fully blocking doses of REVIAa suggested plan of management is regional analgesiaconscious sedation with a benzodiazepineuse of non-opioid analgesics or general anesthesia.

Nausea vomiting stomach pain or cramping diarrhea constipation loss of appetite headache dizziness anxiety nervousness irritability tearfulness difficulty falling or staying asleep increased or decreased energy drowsiness muscle or joint pain rash.

In the clinical studiestreatment with REVIA supported abstinenceprevented relapse and decreased alcohol consumptionIn the uncontrolled studythe patterns of abstinence and relapse were similar to those observed in the controlled studiesREVIA was not uniformly helpful to all patientsand the expected effect of the drug is a modest improvement in the outcome of conventional treatment.

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