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A 24-month study in rats and a 21-month study in mice showed no evidence of carcinogenicityThere was also no mutagenic response in in vitro bacterial testsNo intrinsic effect on fertility was observed in rats.

If you take this medicine after the expiry date has passedit may not work as well.

Like other calcium antagonistsdiltiazem decreases sinoatrial and atrioventricular conduction in isolated tissues and has a negative inotropic effect in isolated preparationsIn the intact animalprolongation of the AH interval can be seen at higher doses.

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