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Overdose symptoms may include feeling very thirsty or hotheavy sweatinghot and dry skinextreme weaknessor fainting.
Investigations into the mode of action of LASIX have utilized micropuncture studies in ratsstop flow experiments in dogs and various clearance studies in both humans and experimental animalsIt has been demonstrated that LASIX inhibits primarily the absorption of sodium and chloride not only in the proximal and distal tubules but also in the loop of HenleThe high degree of efficacy is largely due to the unique site of actionThe action on the distal tubule is independent of any inhibitory effect on carbonic anhydrase and aldosterone.
In patients with hepatic cirrhosis and ascitesLASIX therapy is best initiated in the hospitalIn hepatic coma and in states of electrolyte depletiontherapy should not be instituted until the basic condition is improvedSudden alterations of fluid and electrolyte balance in patients with cirrhosis may precipitate hepatic comathereforestrict observation is necessary during the period of diuresisSupplemental potassium chloride andif requiredan aldosterone antagonist are helpful in preventing hypokalemia and metabolic alkalosis.
Potentiation occurs with ganglionic or peripheral adrenergic blocking drugs.
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