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Patients taking concomitant oral corticosteroidsselective serotonin reuptake inhibitorsSSRIsor anti-platelet agents such as low-dose acetylsalicylic acid are at increased risk of serious GI complicationssee below and section 4.5As with other NSAIDsthe use of piroxicam in combination with protective agentse.gmisoprostol or proton pump inhibitorsmust be considered for these at-risk patients.

Inform patients of the signs of an anaphylactic reactione.gdifficulty breathingswelling of the face or throatInstruct patients to seek immediate emergency help if these occursee CONTRAINDICATIONS and WARNINGS AND PRECAUTIONS

NSAIDsincluding piroxicamcan cause serious skin adverse reactions such as exfoliative dermatitisStevensJohnson SyndromeSJSand toxic epidermal necrolysisTENwhich can be fatalThese serious events may occur without warningInform patients about the signs and symptoms of serious skin reactionsand to discontinue the use of FELDENE at the first appearance of skin rash or any other sign of hypersensitivityFELDENE is contraindicated in patients with previous serious skin reactions to NSAIDssee CONTRAINDICATIONS

A subpopulation of patients with asthma may have aspirin-sensitive asthma which may include chronic rhinosinusitis complicated by nasal polypsseverepotentially fatal bronchospasmand/or intolerance to aspirin and other NSAIDsBecause cross-reactivity between aspirin and other NSAIDs has been reported in such aspirin-sensitive patientsFELDENE is contraindicated in patients with this form of aspirin sensitivitysee CONTRAINDICATIONSWhen FELDENE is used in patients with preexisting asthmawithout known aspirin sensitivitymonitor patients for changes in the signs and symptoms of asthma.

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