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Due to the alpha 1receptor blocking activity of labetalol HClblood pressure is lowered more in the standing than in the supine positionand symptoms of postural hypotension2including rare instances of syncopecan occurFollowing oral administrationwhen postural hypotension has occurredit has been transient and is uncommon when the recommended starting dose and titration increments are closely followedsee DOSAGE AND ADMINISTRATIONSymptomatic postural hypotension is most likely to occur 2 to 4 hours after a doseespecially following the use of large initial doses or upon large changes in dose.

Labetalol can pass into breast milk and may harm a nursing babyDo not use this medication without telling your doctor if you are breast-feeding a baby.

Labetalol HCl combines both selectivecompetitivealpha 1adrenergic blocking and nonselectivecompetitivebeta-adrenergic blocking activity in a single substanceIn manthe ratios of alphato beta-blockade have been estimated to be approximately 1:3 and 1:7 following oral and intravenousIVadministrationrespectivelyBeta 2agonist activity has been demonstrated in animals with minimal beta 1agonistISAactivity detectedIn animalsat doses greater than those required for alphaor beta-adrenergic blockadea membrane stabilizing effect has been demonstrated.

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