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Mao inhibitors – do not combine pimozide orap – do not combine drugs that prolong the qt interval warfarin coumadin – may increase effect of warfarin carbamazepine tegretol – may reduce sertraline levels cimetidine tagamet – may increase sertraline levels serotonergic drugs – may increase risk of serotonin syndrome anticoagulant antiplatelet meds – may increase bleeding risk cyp2d6 substrates – sertraline is a weak cyp2d6 inhibitor.

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Some of these cardiovascular complications have resulted in fatalitiesMyocardial infarction has been associated with other tricyclic compounds.

In additionTegretol causesor would be expected to causedecreased levels of the following drugsfor which monitoring of concentrations or dosage adjustment may be necessaryacetaminophenalbendazolealprazolamaprepitantbuprenorphonebupropioncitalopramclonazepamclozapinecorticosteroidse.gprednisolonedexamethasonecyclosporinedicumaroldihydropyridine calcium channel blockerse.gfelodipinedoxycyclineethosuximideeverolimushaloperidolimatinibitraconazolelamotriginelevothyroxinemethadonemethsuximidemianserinmidazolamolanzapineoral and other hormonal contraceptivesoxcarbazepinepaliperidonephensuximidephenytoinpraziquantelprotease inhibitorsrisperidonesertralinesirolimustadalafiltheophyllinetiagabinetopiramatetramadoltrazodonetricyclic antidepressantse.gimipramineamitriptylinenortriptylinevalproatewarfarinziprasidonezonisamide.

Abnormalities in liver function testscholestatic and hepatocellular jaundicehepatitisvery rare cases of hepatic failure.

Therapy should be prescribed only after critical benefit-to-risk appraisal in patients with a history of cardiac conduction disturbanceincluding second-and third-degree AV heart blockcardiachepaticor renal damageadverse hematologic or hypersensitivity reaction to other drugsincluding reactions to other anticonvulsantsor interrupted courses of therapy with Tegretol.

Monitoring of blood levels has increased the efficacy and safety of anticonvulsantssee PRECAUTIONSLaboratory TestsDosage should be adjusted to the needs of the individual patientA low initial daily dosage with a gradual increase is advisedAs soon as adequate control is achievedthe dosage may be reduced very gradually to the minimum effective levelMedication should be taken with meals.

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