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ClomiPHENE citrate is capable of interacting with estrogen-receptor-containing tissuesincluding the hypothalamuspituitaryovaryendometriumvaginaand cervixIt may compete with estrogen for estrogen-receptor-binding sites and may delay replenishment of intracellular estrogen receptorsClomiPHENE citrate initiates a series of endocrine events culminating in a preovulatory gonadotropin surge and subsequent follicular ruptureThe first endocrine event in response to a course of clomiPHENE citrate therapy is an increase in the release of pituitary gonadotropinsThis initiates steroidogenesis and folliculogenesisresulting in growth of the ovarian follicle and an increase in the circulating level of estradiolFollowing ovulationplasma progesterone and estradiol rise and fall as they would in a normal ovulatory cycle.

Signs of an allergic reactionlike rashhivesitchingredswollenblisteredor peeling skin with or without feverwheezingtightness in the chest or throattrouble breathingswallowingor talkingunusual hoarsenessor swelling of the mouthfacelipstongueor throatSigns of a pancreas problempancreatitislike very bad stomach painvery bad back painor very bad upset stomach or throwing upVery bad dizziness or passing outSwellingwarmthnumbnesschange of coloror pain in a leg or armEyesight changeslike blurred eyesight or seeing spots or flashesmay happenThey may show up or get worse in bright lightThe chance that this will happen is greater in people who take Seropheneclomiphenein higher doses or for a long timeEyesight most often gets back to normal when the drug is stoppedThe changes may be long-lasting or may not go away even after the drug is stoppedUse care when driving or doing other tasks that call for clear eyesightCall your doctor right away if you have a change in eyesightA very bad ovary problem may happen with SeropheneclomipheneCall your doctor right away if you have very bad stomach pain or bloatingupset stomach or throwing uploose stoolsdiarrheaweight gainshortness of breathor a change in how much urine is passed.

This medication is used to treat infertility in womenIt works by stimulating an increase in the amount of hormones that support the growth and release of a mature eggovulationThis medication is not recommended for women whose ovaries no longer make eggs properlyprimary pituitary or ovarian failure

Visual DisordersAbnormal accommodationcataracteye painmacular edemaoptic neuritisphotopsiaposterior vitreous detachmentretinal hemorrhageretinal thrombosisretinal vascular spasmtemporary loss of vision.

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