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Generic form of imuran the letter explained that auditors had pegged the cost of fixing the house and raising it up on a higher foundation at less than the family had already received from their insurance policies and a low-interest federal disaster loan.

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Caution is necessary during the administration of Imuran to patients with hepatic dysfunctionand regular complete blood counts and liver function tests should be undertakenIn such patients the metabolism of Imuran may be impairedand the dosage of Imuran should therefore be reduced if hepatic or haematological toxicity occurs.

It has been suggested that the toxicity of Imuran may be enhanced in the presence of renal insufficiencybut controlled studies have not supported this suggestionNeverthelessit is recommended that the dosages used should be at the lower end of the normal range and that haematological response should be carefully monitoredDosage should be further reduced if haematological toxicity occurs.

Azathioprine and/or its metabolites have been found in low concentrations in foetal blood and amniotic fluid after maternal administration of azathioprine.

Alterations in specific immune responses or immunologic functions in transplant recipients are difficult to relate specifically to immunosuppression by azathioprineThese patients have subnormal responses to vaccineslow numbers of T-cellsand abnormal phagocytosis by peripheral blood cellsbut their mitogenic responsesserum immunoglobulinsand secondary antibody responses are usually normal.

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