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Take this medication by mouth with or without food as directed by your doctorusually 3 times a dayTo reduce your risk of side effectsyour doctor may direct you to start this medication at a low dose and gradually increase your doseFollow your doctor’s instructions carefully.

Seizures have been reported during overdose and with withdrawal from LIORESAL INTRATHECAL as well as in patients maintained on therapeutic doses of LIORESAL INTRATHECAL.

Intrathecal massCases of intrathecal mass at the tip of the implanted catheter have been reportedmost of them involving pharmacy compounded analgesic admixturesThe most frequent symptoms associated with intrathecal mass are1decreased therapeutic responseworsening spasticityreturn of spasticity when previously well controlledwithdrawal symptomspoor response to escalating dosesor frequent or large dosage increases2pain3neurological deficit/dysfunctionClinicians should monitor patients on intraspinal therapy carefully for any new neurological signs or symptomsIn patients with new neurological signs or symptoms suggestive of an intrathecal massconsider a neurosurgical consultationsince many of the symptoms of inflammatory mass are not unlike the symptoms experienced by patients with severe spasticity from their diseaseIn some casesperformance of an imaging procedure may be appropriate to confirm or rule-out the diagnosis of an intrathecal mass.

It is not known whether this drug is excreted in human milkAs a general rulenursing should not be undertaken while a patient is on a drug since many drugs are excreted in human milk.

An attempt should be made to discontinue concomitant oral antispasticity medication to avoid possible overdose or adverse drug interactionseither prior to screening or following implant and initiation of chronic LIORESAL INTRATHECAL infusionReduction and discontinuation of oral anti-spasmotics should be done slowly and with careful monitoring by the physicianAbrupt reduction or discontinuation of concomitant antispastics should be avoided.

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infants exposed to lioresal through maternal oral dosing during pregnancy are at risk of experiencing baclofen withdrawal at birth; identification of this condition may be confounded due to delayed appearance of withdrawal symptoms in this population.