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KEPPRA may cause behavioral abnormalities and psychotic symptomsPatients treated with KEPPRA should be monitored for psychiatric signs and symptoms.

Table 3Adverse Reactions in Pooled Placebo-ControlledAdd-On Studies in Adults Experiencing Partial Onset Seizures.

Table 9 lists adverse reactions that occurred in at least 5of idiopathic generalized epilepsy patients experiencing PGTC seizures treated with KEPPRA and were numerically more common than in patients treated with placeboIn this studyeither KEPPRA or placebo was added to concurrent AED therapy.

KEPPRA is indicated as adjunctive therapy in the treatment of myoclonic seizures in adults and adolescents 12 years of age and older with juvenile myoclonic epilepsy.

In all of these studiesthe main measure of effectiveness was the change in the number of seizures before and during treatment.

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