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Treatment is usually initiated with a dose of 1 to 2 mg daily of estradioladjusted as necessary to control presenting symptomsthe minimal effective dose for maintenance therapy should be determined by titration.

The WHI estrogen-plus-progestin substudy demonstrated an increased risk of invasive breast cancer.

In a small number of case reportssubstantial increases in blood pressure have been attributed to idiosyncratic reactions to estrogensIn a largerandomizedplacebo-controlled clinical triala generalized effect of estrogens on blood pressure was not seenBlood pressure should be monitored at regular intervals with estrogen use.

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i am on estrace 6mg daily as well.